几十年来,医生们注意到,黑色素瘤等多种类型的癌症中,癌细胞往往会先扩散到淋巴结,然后再通过血流“播种”到远处的器官。“以前的研究大多集中在癌细胞如何通过血液转移,对癌细胞经淋巴迁移的过程知之甚少。” 这项研究的负责人、德克萨斯大学西南医学中心(University of Texas Southwestern Medical Center)的Sean Morrison教授说。
参考资料
[1] Jessalyn M. Ubellacker et al., (2020) Lymph protects metastasizing melanoma cells from ferroptosis. Nature. DOI: https://doi.org/10.1038/s41586-020-2623-z
[2] Barbara M. Grüner & Sarah-Maria Fendt (2020) Cancer cells stock up in lymph vessels to survive. Nature. DOI: 10.1038/d41586-020-02383-5
[3] The secret of lymph: How lymph nodes help cancer cells spread Retrieved Aug. 23, 2020 from https://medicalxpress.com/news/2020-08-secret-lymph-nodes-cancer-cells.html